Cold Agglutination Test

Description

The Cold Agglutination Test detects the presence of cold-reactive antibodies in the blood, which can cause red blood cells to clump together at low temperatures. It’s primarily used to diagnose cold agglutinin disease, a rare type of autoimmune hemolytic anemia. The test involves observing blood samples at different temperatures to see if agglutination occurs. Positive results can indicate cold agglutinin disease, certain infections (like mycoplasma pneumonia), or lymphoproliferative disorders. The test helps in differentiating between different types of hemolytic anemias and guiding appropriate treatment strategies. It’s particularly important in patients with symptoms of anemia that worsen in cold environments.